Schreiner launches deep-freeze tamper seal

Schreiner MediPharm has developed a transparent deep-freeze seal for pharmaceutical folding boxes that maintains adhesion and tamper evidence at storage temperatures down to -196°C, addressing a gap in packaging security for mRNA substances, biologics and cell and gene therapies stored and transported at extreme sub-zero temperatures.

Conventional security seals can lose adhesion at deep-freeze temperatures, compromising the tamper evidence required under the EU Falsified Medicines Directive and ISO 21976, both of which mandate tamper-evident packaging for prescription drugs.

The new seal uses a multi-tear effect as a double security mechanism. Attempts to remove it cause the film to tear irreversibly through integrated security cuts and, depending on the cardboard surface, pull fibers from the folding box, making tampering immediately visible. An integrated guilloche provides an additional authentication feature, with further overt, semi-covert or covert security elements available according to the threat scenario.

The seal is available in two variants: one designed for dispensing at 10°C and one for application down to -50°C. Both comply with the EU Falsified Medicines Directive and ISO 21976.